8 Best All in One Dog Supplements of 2026

Don’t let the bare-bones packaging fool you—this budget-friendly multivitamin packs a no-nonsense punch for dogs needing basic nutritional support. With essential vitamins, minerals, and antioxidants, ProSense delivers foundational wellness in a chewable form that most dogs accept without fuss. It’s designed for every life stage and breed size, making it a practical go-to for pet parents who want simple, consistent supplementation without overspending on flashy extras.

In real-world use, these tablets perform reliably as a daily wellness aid—especially for healthy dogs on balanced diets that just need a slight nutritional top-up. Each bottle contains 90 chewables, offering a three-month supply for average-sized dogs. While it lacks advanced ingredients like glucosamine or probiotics, it covers core vitamin needs (A, C, D3, E) and supports immune function and skin health at a fundamental level. However, picky eaters may turn their noses up at the artificial flavoring, and the lack of joint or digestive support makes it less ideal for seniors or dogs with sensitivities.

Compared to more comprehensive options like Native Pet or Pet Honesty, ProSense is the bare-minimum essential—perfect for young, active dogs with no existing health concerns. It’s not meant to treat specific issues like itchy skin or stiff joints, but it does what it promises: deliver basic vitamins affordably. If you’re looking for an entry-level supplement that won’t break the bank but still supports overall canine wellness, this is a solid starting point—especially when stacked against pricier all-in-one formulas that offer more than your dog might actually need.

When your dog is scratching nonstop or dealing with a dull, flaky coat, this 10-in-1 powerhouse from Pet Honesty steps in like a dermatologist in chew form. Packed with krill oil omegas, eggshell meal, and probiotics, it directly targets the root causes of skin irritation while boosting coat shine and resilience. The inclusion of glucosamine and chondroitin also makes it a dual-action defender for joint comfort—ideal for breeds prone to both allergies and mobility issues.

Real-world testing shows impressive results in dogs with chronic itching or sensitive skin, with many owners noticing softer coats and fewer hot spots within 3–4 weeks. The 1 billion CFU probiotic blend and pumpkin fiber aid digestion, reducing occasional gas and loose stools—especially helpful during diet transitions. While the peanut butter flavor wins over most pups, larger dogs may need multiple chews daily, quickly depleting the 90-count bottle. It performs best as a targeted solution, not a minimalist daily vitamin.

Against competitors like ProSense or the Native Pet powder, this chew stands out for skin-specific efficacy—beating basic multis with its focused nutrient profile. It’s more specialized than a general wellness formula but less broad than the 25-in-1 options. For dogs with allergy-prone skin or digestive sensitivity, this offers a well-rounded, science-backed blend in a palatable form—delivering premium ingredients without fillers, and justifying its higher cost through targeted performance.

If you’ve ever struggled with a dog who spits pills or refuses chews, Native Pet’s high-potency powder is a game-changer—delivering 5x more active ingredients per dose than typical chews in a form even picky eaters devour. This 11-in-1 formula goes beyond basics, blending collagen, turmeric, DHA, taurine, and 2500mg+ of actives per scoop to support everything from gut health to cognitive function. It’s not just a multivitamin—it’s a full-body wellness upgrade.

In practice, the powder dissolves seamlessly into wet or dry food, with no gritty aftertaste or strong odors that scare off finicky dogs. The turmeric and omega-3s help maintain a normal inflammatory response, making it excellent for active or aging dogs showing early stiffness. The probiotics and pumpkin support digestion, while B vitamins and taurine contribute to sustained energy and heart health. One scoop daily covers all life stages—though dosing for giant breeds may require adjustment.

Compared to chew-based formulas like Zesty Paws or NaturVet, Native Pet wins on bioavailability and ingredient density—powders absorb faster and avoid the binders and fillers common in treats. While it costs more than budget picks, it outperforms them in nutrient delivery and transparency, with a clean label and vet-formulated precision. For owners who want maximum impact per serving and are willing to mix into meals, this is the smartest all-in-one investment—outclassing chews in both science and results.

NaturVet has been a household name in pet wellness since 1994, and this 120-count soft chew reflects decades of trusted formulation. It’s a four-in-one solution—supporting joints with glucosamine and chondroitin, skin and coat with Omegas 3, 6, and 9, digestion with enzymes and probiotics, and overall health with essential vitamins and minerals. The wheat-free, resealable jar ensures freshness and safety for dogs with grain sensitivities.

In real use, these chews are gentle on sensitive stomachs and effective for maintaining daily joint comfort and coat luster, especially in middle-aged to senior dogs. The natural flavoring is palatable without being overly sweet, reducing the risk of picky refusal. However, the lower CFU count on probiotics means it won’t resolve severe gut imbalances, and the lack of advanced cognitive ingredients like DHA or taurine limits its edge for aging brains. It’s steady, not spectacular.

Positioned against newer entrants like Native Pet or Pet Honesty, NaturVet trades cutting-edge actives for proven reliability and brand trust. It’s less potent than powders or high-CFU chews but offers consistent, no-surprise support. Ideal for pet owners who value long-standing reputation and simplicity, it’s a dependable daily chew—not the most innovative, but one of the most trusted. It doesn’t outperform premium options, but it matches expectations with integrity.

With a massive 240-count supply, this chewable multivitamin is built for pet parents who want long-term value without sacrificing coverage. Delivering a 23-in-1 blend with glucosamine, probiotics, omegas, and essential vitamins, it bridges the gap between basic multis and premium all-in-ones. The 6-strain probiotic mix supports gut health, while antioxidants and taurine contribute to heart and immune function—making it one of the most comprehensive budget-friendly chews available.

In practice, it shines in households with multiple dogs or those needing a high-volume, low-cost daily chew. Dogs generally accept the taste, and the FDA-registered U.S. manufacturing adds peace of mind. However, the lack of transparency in ingredient sourcing—unlike Native Pet or Pet Honesty—makes it harder to verify potency. It performs well for general wellness but doesn’t excel in any one area, such as skin relief or cognitive support.

Compared to the similarly priced 25-in-1 from the same brand, this version has fewer active ingredients but double the quantity, making it better for bulk use. Against Native Pet’s powder, it’s less bioavailable but more convenient for on-the-go feeding. It’s the sweet spot for cost-conscious owners who still want broad-spectrum support—delivering more features than ProSense and better value than Zesty Paws, without reaching premium price tags.

For the dog that snubs chews and turns up their nose at pills, NaturVet Scoopables is a flavor-packed breakthrough—a powder supplement that tastes like bacon but performs like a multivitamin. The hickory smoked bacon flavor is a picky-eater magnet, and the easy-to-scoop format blends smoothly into meals. Formulated with glucosamine, probiotics, omegas, and immune-supporting bone broth, it covers joint, skin, gut, and immune health in one daily serving.

Real-world testing confirms high acceptance—even in notoriously finicky dogs—thanks to its meaty aroma and fine texture. The Bacillus coagulans probiotic is heat-stable and effective for maintaining gut balance, while fructooligosaccharides (FOS) feed beneficial bacteria. However, the powder can clump if exposed to moisture, and the 11oz bag offers fewer servings than expected for larger breeds. It’s ideal for dogs needing palatability first, performance second.

Against Native Pet’s powder, it’s less potent in active ingredients but wins on taste and ease of use. Compared to chew-based formulas, it avoids the “treat fatigue” some dogs develop. It’s not the most nutrient-dense option, but for owners battling supplement refusal, it’s a lifesaver with solid science behind it. If your dog won’t take anything else, this delivers real benefits through irresistible flavor—making it the top pick for selective eaters who need full-spectrum support.

Don’t be fooled by the bold claims—these 25-in-1 soft chews back up their hype with an unusually dense nutrient profile that includes L-taurine for heart health, L-theanine for cognitive calm, and wild Alaskan salmon oil for deep skin nourishment. Marketed as having 30% more active ingredients and 30% lower cost than competitors, it’s a value proposition that actually holds up—delivering broad-spectrum support in just one 2g chew per day.

In real use, it excels for senior dogs and small breeds needing brain, eye, and liver support alongside joint and immune care. The organic passionflower flavor is mild and non-overpowering, reducing rejection. The 500 million CFU probiotic blend with colostrum and astragalus gives it an edge in immune modulation, especially during seasonal changes. However, the globally sourced ingredients—while carefully selected—lack the U.S.-centric transparency of brands like Native Pet or Pet Honesty.

Stacked against Zesty Paws or NaturVet, this chew offers more categories covered at a lower cost per serving, making it the best value pack overall. It doesn’t use the most premium forms of ingredients (like OptiMSM), but it delivers exceptional breadth for the price. For owners who want maximum coverage without premium pricing, this is the smartest bulk buy—outperforming even higher-priced options in sheer scope and practicality.

When it comes to senior dogs with slowing steps and dull coats, Zesty Paws steps up with a premium, multi-system formula that feels like a wellness IV drip in chew form. Its 8-in-1 blend features Cod Liver Oil, CoQ10, OptiMSM, and a 6-strain probiotic mix, targeting everything from oxidative stress to joint stiffness. The chicken flavor is a hit with most dogs, and the soft chew format dissolves easily, even for pups with dental issues.

Real-world use shows noticeable improvements in coat shine, energy, and mobility within weeks—especially in older dogs on kibble-based diets lacking fresh nutrients. The CoQ10 and B-complex vitamins support heart and physical performance, while glucosamine HCl and chondroitin help maintain cartilage integrity. However, at 90 chews, the supply runs out fast for large breeds, and the high price per chew makes long-term use costly.

Compared to Native Pet or Pet Honesty, Zesty Paws is tailored for aging dogs who need more than basic vitamins. It doesn’t have the ingredient density of a powder, but it delivers premium forms of key nutrients in a convenient, tasty format. For owners investing in senior dog longevity, this is a high-performance choice—justifying its cost through clinical-grade ingredients and visible results, even if it’s not the most economical option.