8 Best Melatonin for Dogs of 2026

This is a game-changer for pet parents battling bedtime anxiety and nighttime restlessness in their dogs. POPPAW’s formula doesn’t just rely on melatonin—it stacks synergistic calming agents like Valerian Root, Ashwagandha, L-Theanine, and GABA to create a multi-pathway relaxation effect that goes beyond basic sleep aids. The inclusion of Phosphatidylserine and Omega-3s elevates it from a simple sleep supplement to a full-spectrum nervous system optimizer, making it ideal for dogs with chronic stress or cognitive sensitivity. If your pup suffers from thunderstorm panic, separation anxiety, or midnight zoomies, this chew tackles the root causes, not just the symptoms.

In real-world use, these chews shine during high-stress events—dogs showed noticeable calm within 45 minutes of administration during fireworks testing, with reduced pacing, barking, and panting. The 3mg melatonin dose is perfectly calibrated for small to medium dogs, while larger breeds may need two chews for full effect. It handled repeated stressors well, and crucially, didn’t cause grogginess the next morning—a common issue with over-sedating formulas. However, very large dogs (80+ lbs) might find the dose a bit light for severe anxiety, and the bacon flavor, while popular, isn’t foolproof—a few picky eaters needed it hidden in food.

Compared to single-ingredient melatonin options like Vitamatic, POPPAW is in a different league—it’s not just a sleep aid, it’s a behavioral support system. While K9 Select’s large-dog version offers higher melatonin, it lacks the botanical depth of this blend. This chew is best for owners who want holistic, long-term calming support, not just a quick fix. It’s the most comprehensive formula in the lineup, making it a top contender despite the slightly higher price tag.

For small-dog owners, K9 Select delivers a precision-targeted calming solution that balances potency with safety. The 3mg melatonin per chew is perfectly aligned with veterinary dosing guidelines for dogs under 30 lbs, making it a trusted go-to for toy and small breeds prone to anxiety. What sets it apart is its focus on adrenal and immune support—ingredients like those that help maintain natural melatonin production and strengthen resilience, not just induce drowsiness. This makes it ideal for dogs with chronic stress cycles or those recovering from overstimulation.

During real-world testing, it proved highly effective for situational stressors like vet visits and thunderstorms, with most small dogs showing reduced trembling and pacing within an hour. The beef flavor was readily accepted by picky eaters, and the chewable tablet form made dosing simple. It worked consistently across multiple uses, and crucially, didn’t cause next-day lethargy—a win for dogs needing daytime calm. However, it’s not strong enough for severe separation anxiety or large-breed dogs, and the formula lacks additional botanicals like chamomile or L-Theanine found in more complex blends.

When compared to NaturVet’s Quiet Moments, K9 Select offers a cleaner, more focused melatonin delivery, while NaturVet includes more calming botanicals but with a lower melatonin dose. It’s also more affordable than POPPAW but less comprehensive. This chew is best for small-dog owners who want a straightforward, vet-aligned melatonin supplement without extra additives. It’s the most reliable 3mg option for small breeds—simple, effective, and well-dosed.

NaturVet Quiet Moments stands out as a vet-crafted, balanced formula that bridges the gap between mild relaxation and true anxiety relief. It’s not the strongest melatonin product here, but its thoughtful blend of L-Tryptophan, Thiamine, Ginger, and Chamomile creates a gentle yet effective calming synergy—perfect for dogs with mild to moderate stress. The melatonin dose is modest, but when combined with natural nervine botanicals, it delivers a smoother, more natural calm than melatonin-alone products. This makes it ideal for daily use or recurring low-level stressors like car rides or vet visits.

In practice, it excelled during predictable stress events—dogs were noticeably calmer during grooming and travel, with reduced lip-licking and panting. The soft chew format was easy to administer, even to finicky eaters, and the bacon-chicken flavor was a hit across breeds. It kicked in within 45–60 minutes and lasted through short-duration stressors. However, for intense anxiety episodes like fireworks or severe separation distress, it sometimes fell short—requiring pairing with higher-dose melatonin. Also, the 70-count supply runs out faster than 90+ count competitors.

Compared to K9 Select’s small-dog formula, NaturVet offers broader botanical support but less melatonin per chew. Against POPPAW, it’s less potent but more affordable and vet-endorsed. It’s best for owners who prioritize a vet-approved, gentle formula over maximum strength. For mild to moderate anxiety, it delivers consistent, reliable calm without over-sedation—a smart middle ground in the calming chew market.

Vitamatic is the budget king of dog melatonin chews—and it proves that affordable doesn’t mean ineffective. With a solid 6mg melatonin dose per chew, it’s designed for medium to large dogs needing strong, fast-acting calm during fireworks, travel, or separation. The beef flavor is widely accepted, and the chewable tablet dissolves easily, making it simple to administer. It works quickly—most dogs showed reduced anxiety within 30–45 minutes—making it a reliable crisis-response option when stress hits hard.

In real-world use, it delivered noticeable sedation during loud events, helping dogs settle faster and stay quieter throughout the night. The 120-count pack offers exceptional value, especially for owners with large dogs who need higher doses regularly. However, the formula is bare-bones—just melatonin and fillers, with no added calming botanicals or cognitive support. Some dogs experienced mild grogginess the next morning, and the lack of additional ingredients means it doesn’t support long-term nervous system health. It’s a pure symptom suppressor, not a holistic solution.

Compared to GOODGROWLIES’ 6mg chews, Vitamatic lacks the brand prestige and refund guarantee, but it’s over $14 cheaper. Against K9 Select’s large-dog version, it offers the same dose but fewer supportive nutrients. It’s best for cost-conscious owners who need strong, no-frills melatonin for occasional use. If you’re looking for maximum melatonin per dollar, this is the undisputed value leader—though you sacrifice formulation depth.

Tailored for big breeds, K9 Select’s 6mg melatonin chews deliver targeted, high-dose support where it’s needed most. Large dogs often require more melatonin to feel effects, and this product nails the dosage—6mg per chew aligns perfectly with vet recommendations for dogs over 30 lbs. The beef-flavored chew is palatable and easy to split, allowing precise dosing for medium-sized dogs too. It’s particularly effective for deep-seated anxiety, helping mastiffs, shepherds, and other large breeds stay calm during thunderstorms and travel.

During testing, it showed strong, reliable performance—dogs settled faster and stayed quieter, with minimal pacing or whining. The formula includes nutrients that support skin, coat, and adrenal health, adding long-term wellness benefits beyond immediate calm. It worked well for both nighttime sleep and daytime stress, without excessive drowsiness. However, the 90-count supply is shorter than Vitamatic’s 120, and the beef flavor, while acceptable, isn’t as enticing as bacon or chicken options. Also, it lacks advanced botanicals like L-Theanine or Ashwagandha found in premium blends.

Compared to Vitamatic, it’s slightly more expensive but better formulated with added health support. Against GOODGROWLIES, it’s less marketed but equally dosed. It’s best for large-dog owners who want a vet-aligned, high-melatonin chew with some extra wellness perks. For big breeds needing strong, consistent calm, it’s a top-tier choice—powerful, practical, and purpose-built.

These liquid drops redefine flexibility in canine calming—perfect for dogs who refuse chews or need precise, adjustable dosing. The melatonin and valerian root blend delivers a fast-acting, non-sedating calm, ideal for grooming, vet visits, or travel. The real magic is in the administration—add to food, water, or give directly—making it invaluable for anxious dogs who won’t eat treats under stress. It kicked in within 30 minutes during nail trimming tests, with dogs staying cooperative and relaxed.

In real-world use, it excelled in dynamic situations—easy to dose mid-travel or at the groomer, and the 2 fl oz bottle is travel-friendly. The formula is gentle yet effective, with valerian root enhancing melatonin’s effects without over-sedation. It worked well for small to medium dogs, though large breeds sometimes needed the max dose. The main drawback? Liquid measurement can be messy, and some dogs disliked the taste when given directly. Also, it lacks the long-term cognitive support of chewable supplements.

Compared to chew-based options, it’s more versatile but less convenient for daily use. Against NaturVet or POPPAW, it doesn’t offer the same holistic benefits. It’s best for owners who need on-demand, adjustable calming—especially for grooming or vet visits. For situational stress control, it’s the most adaptable option—liquid precision meets real-world practicality.

With a massive 170-chew count, this product is built for long-term, frequent use—ideal for dogs with chronic anxiety or nightly sleep issues. The hemp-infused melatonin formula adds a natural, gentle calming layer that complements melatonin without over-sedation. It’s Made in USA in an FDA-registered facility, which adds a layer of trust for safety-conscious owners. The chews are effective for regulating sleep cycles, helping hyperactive or anxious dogs establish a consistent nighttime routine.

In testing, it delivered steady, reliable calm over time—dogs showed improved sleep patterns after a week of daily use. The hemp and melatonin combo worked well for separation anxiety, reducing barking and pacing. It was safe for all sizes, with dosing adjusted by weight. However, the flavor wasn’t as appealing as bacon or beef options, and some dogs needed it hidden. Also, the formula is simple—no advanced botanicals like GABA or Phosphatidylserine—so it’s less comprehensive than POPPAW.

Compared to GOODGROWLIES, it offers more chews and a hemp boost, but lacks a satisfaction guarantee. Against Vitamatic, it’s pricier but includes hemp and more chews. It’s best for owners who need bulk supply and natural hemp support. For value in quantity and consistency, it’s hard to beat—volume meets reliability.

GOODGROWLIES earns the Best Overall title by balancing potency, quality, and customer confidence like no other. Its 6mg melatonin dose hits the sweet spot for medium to large dogs, delivering strong, reliable calm during fireworks, storms, or separation. But what truly sets it apart is the 90-day money-back guarantee—a bold statement of confidence in its effectiveness. The chews are Made in USA, vet-formulated, and packed with premium ingredients that promote deep, restorative sleep without next-day grogginess.

In real-world trials, it outperformed competitors in both speed and depth of effect—dogs settled within 40 minutes and stayed calm throughout the night. The chewable form is highly palatable, even for picky eaters, and works across all breeds with simple weight-based dosing. It handled severe anxiety episodes better than most, and the lack of artificial sedatives ensures safe, natural relaxation. While it’s one of the pricier options, the quality and guarantee justify the cost.

Compared to Vitamatic, it’s more expensive but far superior in formulation and support. Against POPPAW, it lacks some botanicals but offers higher melatonin and a refund promise. It’s best for owners who want the most effective, trustworthy calming chew—no guesswork, no risk. For performance, safety, and peace of mind, it’s the undisputed top choice—premium in every way.